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Professor Gong Guoli's team has made new progress in the study of antibacterial mechanism of natural products
2021/07/01 20:48 Wang Xuyang

Recently, Professor Gong Guoli's team published online the evaluation of the membrane damage mechanism of Protocatechualdehyde against in the top journal Food Chemistry (SCI impact factor 6.306) of the first district of Chinese Academy of Sciences Yersinia enterocolitica And Simulation of growth inhibition in pork The antibacterial mechanism of Yersinia enterocolitica provides a theoretical basis for controlling the contamination of Yersinia enterocolitica in food industry. This paper takes Shaanxi University of science and technology as the only completed unit, Gong Guoli as the corresponding author, Tian Lu as the first author and Wang Xuyang as the second author.

Yersinia enterocolitica is widely distributed in nature. Its pathogenic strain is one of the zoonotic pathogens prevalent in animal hosts (especially pigs). The pathogen has been present in the pork production chain from the very beginning, and Yersinia enterocolitica can be detected and associated with it after eating contaminated pork. As of 2011, at least 8000 patients in Europe and America were infected with Yersinia enterocolitica due to contaminated food, causing huge economic losses. However, the traditional high-temperature sterilization and chemical preservative treatment can not be carried out in the production and sales process of raw pork, so it is difficult to ensure food safety. Therefore, more efforts are needed to overcome the food safety problems caused by Yersinia enterocolitica infection. In recent years, there are more and more studies on the safety and antibacterial activity of natural plant extracts. Protocatechuic aldehyde is a kind of natural polyphenol compounds, mainly from Salvia miltiorrhiza( Salvia miltiorrhiza )It was isolated from plants. The aim of this study was to investigate the antibacterial activity of protocatechuic aldehyde against Yersinia enterocolitica and its possible mechanism. We systematically evaluated the changes of membrane morphology and function of Yersinia enterocolitica treated with protocatechuic aldehyde at different doses. The bacteriostatic effect of protocatechuic aldehyde on Yersinia enterocolitica was verified in pork.

The results showed that protocatechuic aldehyde could effectively inhibit the growth of Yersinia enterocolitica by destroying the integrity of plasma membrane, resulting in the disorder of intracellular environment, membrane depolarization and decrease of Phin. The dynamic collapse of proton gradient and depletion of ATP pool may be the main causes of membrane damage through the disorder of ion channels and the destruction of specific targets on the membrane. Protocatechuic aldehyde can also effectively prevent the contamination of Yersinia enterocolitica in pork.

Link to the original text: http://doi.org/10.1016/j.foodchem.2021.130340

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